盐酸氨溴索片和盐酸溴己新片治疗2型糖尿病肺部感染的效果比较(1)
[摘要]目的 比较盐酸氨溴索片和盐酸溴己新片治疗2型糖尿病肺部感染的效果。方法 选取2014年10月～2016年2月我院门诊收治的2型糖尿病合并肺部感染患者80例，按照就诊ID号将患者随机分为观察组与对照组，所有患者给予哌拉西林/舒巴坦静脉滴注治疗，在此基础上对照组患者加用盐酸氨溴索片治疗，观察组患者加用盐酸溴己新片治疗，比较两组的临床疗效以及病情治疗情况。结果 观察组发热消失时间[(1.51±0.41)h]、咳嗽咳痰消失时间[(1.92±0.32)d]以及住院时间[(12.1±2.9)d]较对照组[(1.84±0.25)h、(2.14±0.43)h、(17.5±3.4)d]顯著缩短(P<0.05)；观察组痰TNF-α[(155.21±23.54)pg/ml]、降钙素原[(0.24±0.03)ng/ml]以及血CRP[(6.42±1.32)mg/L]较对照组[(201.35±26.54)pg/ml、(0.31±0.04)ng/ml、(7.34±1.35)mg/L]显著下降(P<0.01)；观察组临床治疗总有效率(92.5%)显著高于对照组(72.5%)(P=0.044)。结论 采用盐酸氨溴索片联合哌拉西林/舒巴坦静脉滴注可有效治疗2型糖尿病患者肺部感染，能显著缩短临床症状改善时间，促进患者更快痊愈，安全可行，可在临床治疗中推广应用。
[关键词]盐酸氨溴索片；盐酸溴己新片；2型糖尿病；肺部感染
[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721(2016)11(a)-0113-03
[Abstract]Objective To compare the clinical effect of Ambroxol Hydrochloride Tablet and Bromhexine Hydrochloride Tablet treating type 2 diabetes mellitus complicated with pulmonary infection.Methods 80 patients with type 2 diabetes mellitus complicated with pulmonary infection treated by our outpatient of our hospital from October 2014 to February 2016 were selected.All patients were randomly divided into observation group and control group according to visiting ID number.All patients were given Piperacillin/Sulbactam for intravenous infusion，on the basis of Piperacillin-Sulbactam for intravenous infusion，patients in control group were given Ambroxol Hydrochloride Tablet and patients in observation group were given Bromhexine Hydrochloride Tablet.The clinical curative effect and treatment situation between two groups were compared.Results The disappearance time of fever in observation group [(1.51±0.41) h]，cough disappeared time [(1.92±0.32) d] and hospitalization time [(12.1±2.9) d] was significantly shortened respectively compared with control group [(1.84±0.25) h，(2.14±0.43) h，(17.5±3.4) d] (P<0.05)；TNF-α[(155.21±23.54) pg/ml]，procalcitonin [(0.24±0.03) ng/ml] and blood CRP [(6.42±1.32) mg/L] was significantly decreased respectively compared with control group [(201.35±26.54) pg/ml，(0.31± 0.04) ng/ml and (7.34±1.35) mg/L] (P<0.01)；the total effective rate of observation group (92.5%) was significantly higher than that of control group (72.5%) (P=0.044).Conclusion Ambroxol Hydrochloride Tablet combined with Piperacillin/Sulbactam for intravenous infusion can effectively treat lung infection of type 2 diabetes mellitus，and obviously shorten clinical symptom improvement time，promote faster recovery of patients and it is safe and feasible.It is can be promoted and applied in clinic. (赵鑫)
[关键词]盐酸氨溴索片；盐酸溴己新片；2型糖尿病；肺部感染
[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721(2016)11(a)-0113-03
[Abstract]Objective To compare the clinical effect of Ambroxol Hydrochloride Tablet and Bromhexine Hydrochloride Tablet treating type 2 diabetes mellitus complicated with pulmonary infection.Methods 80 patients with type 2 diabetes mellitus complicated with pulmonary infection treated by our outpatient of our hospital from October 2014 to February 2016 were selected.All patients were randomly divided into observation group and control group according to visiting ID number.All patients were given Piperacillin/Sulbactam for intravenous infusion，on the basis of Piperacillin-Sulbactam for intravenous infusion，patients in control group were given Ambroxol Hydrochloride Tablet and patients in observation group were given Bromhexine Hydrochloride Tablet.The clinical curative effect and treatment situation between two groups were compared.Results The disappearance time of fever in observation group [(1.51±0.41) h]，cough disappeared time [(1.92±0.32) d] and hospitalization time [(12.1±2.9) d] was significantly shortened respectively compared with control group [(1.84±0.25) h，(2.14±0.43) h，(17.5±3.4) d] (P<0.05)；TNF-α[(155.21±23.54) pg/ml]，procalcitonin [(0.24±0.03) ng/ml] and blood CRP [(6.42±1.32) mg/L] was significantly decreased respectively compared with control group [(201.35±26.54) pg/ml，(0.31± 0.04) ng/ml and (7.34±1.35) mg/L] (P<0.01)；the total effective rate of observation group (92.5%) was significantly higher than that of control group (72.5%) (P=0.044).Conclusion Ambroxol Hydrochloride Tablet combined with Piperacillin/Sulbactam for intravenous infusion can effectively treat lung infection of type 2 diabetes mellitus，and obviously shorten clinical symptom improvement time，promote faster recovery of patients and it is safe and feasible.It is can be promoted and applied in clinic. (赵鑫)